It is an oral medication that is utilized for treating
weakness (the failure to achieve or keep up a penile erection), otherwise
called erectile dysfunction (ED). It is in a class of medications called phosphodiesterase
inhibitors that likewise incorporates tadalafil (Cialis), sildenafil (Viagra)
and vardenafil (Levitra). The erection of the penis is brought about by the filling
of the penis with blood. Filling happens because the veins that
carry blood to the penis increment in size and convey more blood to the penis,
and, simultaneously, the veins that remove blood from the penis decline in size
and expel less blood from the penis. Sexual incitement that prompts an erection
causes the creation and arrival of nitric oxide in the penis. The nitric oxide
causes a protein, guanylate cyclase, to create cyclic guanosine monophosphate
(cGMP). It is cGMP that is essentially in charge of expanding and diminishing
the size of veins conveying blood to and from the penis, separately, and
causing an erection. At the point when the cGMP is obliterated by another
catalyst, phosphodiesterase-5, the veins come back to their typical size, blood
leaves the penis, and the erection closes. Avanafil anticipates phosphodiesterase-5
from crushing cGMP so that cGMP remains around longer. The industriousness of
cGMP prompts a progressively delayed engorgement of the penis with blood.